The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?

被引：9
|
作者：
Hall, Matthew D. [1 ]
Ebert, Dieter [1 ]
机构：
[1] Univ Basel, Inst Zool, CH-4051 Basel, Switzerland
来源：
BMC BIOLOGY | 2013年 / 11卷
基金：
瑞士国家科学基金会;
关键词：
MISSING HERITABILITY; ANTIVIRAL RESISTANCE; EVOLUTION; HOST; DROSOPHILA; RECOMBINATION; ARCHITECTURE; COEVOLUTION; ENVIRONMENT; MECHANISMS;
D O I：
10.1186/1741-7007-11-79
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Interactions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial. Here, we focus on the debate surrounding the evolutionary importance of interactions between resistance loci and argue that its role in explaining overall variance in disease outcomes may have been overestimated.
引用
收藏
页数：5
相关论文
共 50 条
  • [1] The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?
    Matthew D Hall
    Dieter Ebert
    [J]. BMC Biology, 11
  • [2] Has familial aggregation in Alzheimer's disease been overestimated?
    Silverman, JM
    Smith, CM
    Marin, DB
    Schmeidler, J
    Birstein, S
    Lantz, M
    Davis, KL
    Mohs, RC
    [J]. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2000, 15 (07) : 631 - 637
  • [3] Has the burden of depression been overestimated?
    Kruijshaar, ME
    Hoeymans, N
    Spijker, J
    Stouthard, MEA
    Essink-Bot, ML
    [J]. BULLETIN OF THE WORLD HEALTH ORGANIZATION, 2005, 83 (06) : 443 - 448
  • [4] HAS THE IMPORTANCE OF PHOTOAUTOTROPHIC PICOPLANKTON BEEN OVERESTIMATED
    FAHNENSTIEL, GL
    REDALJE, DG
    LOHRENZ, SE
    [J]. LIMNOLOGY AND OCEANOGRAPHY, 1994, 39 (02) : 432 - 438
  • [5] Genetics of susceptibility to human infectious disease
    Cooke, GS
    Hill, AVS
    [J]. NATURE REVIEWS GENETICS, 2001, 2 (12) : 967 - 977
  • [6] Genetics and genomics of infectious disease susceptibility
    Hill, AVS
    [J]. BRITISH MEDICAL BULLETIN, 1999, 55 (02) : 401 - 413
  • [7] Genetics and genomics in infectious disease susceptibility
    Blackwell, JM
    [J]. TRENDS IN MOLECULAR MEDICINE, 2001, 7 (11) : 521 - 526
  • [8] Has the incidence of pelvic inflammatory disease following chlamydial infection been overestimated?
    Simms, I.
    Hornert, P.
    [J]. INTERNATIONAL JOURNAL OF STD & AIDS, 2008, 19 (04) : 285 - 286
  • [9] Has the impact of endoreduplication on cell size been overestimated?
    Tsukaya, Hirokazu
    [J]. NEW PHYTOLOGIST, 2019, 223 (01) : 11 - 15
  • [10] Has the international normalized ratio (INR) been overestimated?
    Roncalés, J
    Lloveras, N
    Juncà, J
    Navarro, T
    [J]. MEDICINA CLINICA, 2005, 124 (18): : 718 - 718
12345