Astrocytes and disease: a neurodevelopmental perspective

被引：504

作者：

Molofsky, Anna V. ^{[2
,4
]}

Krenick, Robert ^{[5
]}

Ullian, Erik ^{[5
]}

Tsai, Hui-hsin ^{[1
,2
,3
]}

Deneen, Benjamin ^{[6
]}

Richardson, William D. ^{[7
,8
]}

Barres, Ben A. ^{[9
]}

Rowitch, David H. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Neurosurg, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

[4] Langley Porter Neuropsychiat Inst, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA 94143 USA

[6] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA

[7] UCL, Wolfson Inst Biomed Res, London WC1E 6BT, England

[8] UCL, Res Dept Cell & Dev Biol, London WC1E 6BT, England

[9] Stanford Univ, Dept Neurobiol, Palo Alto, CA 94305 USA

来源：

GENES & DEVELOPMENT | 2012年 / 26卷 / 09期

关键词：

Rett syndrome; astrocyte; development; disease; heterogeneity; neurodevelopment; neuropsychiatric; FIBRILLARY ACIDIC PROTEIN; BLOOD-BRAIN-BARRIER; NERVOUS-SYSTEM; GLIAL-CELLS; RETT-SYNDROME; PROTOPLASMIC ASTROCYTES; ELECTRON-MICROSCOPY; NEURON INTERACTIONS; PREFRONTAL CORTEX; SECRETED PROTEINS;

D O I：

10.1101/gad.188326.112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies indicate that astrocytes are morphologically and functionally diverse and play critical roles in neurodevelopmental diseases such as Rett syndrome and fragile X mental retardation. This review summarizes recent advances in astrocyte development, including the role of neural tube patterning in specification and developmental functions of astrocytes during synaptogenesis. We propose here that a precise understanding of astrocyte development is critical to defining heterogeneity and could lead advances in understanding and treating a variety of neuropsychiatric diseases.

引用

页码：891 / 907

页数：17

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