An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules

被引：17
|
作者：
Li, Jie [1 ]
Zhang, Linlin [2 ]
Liu, Yang [1 ,3 ,4 ]
Wen, Jing [5 ]
Wu, Di [1 ]
Xu, Duo [1 ]
Segura, Tatiana [1 ]
Jin, Jing [6 ]
Lu, Yunfeng [1 ]
Wang, Hui [2 ]
机构：
[1] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA
[2] Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Nucl Med, Shanghai 200092, Peoples R China
[3] Nankai Univ, Key Lab Funct Polymer Mat, Minist Educ, Tianjin 300071, Peoples R China
[4] Nankai Univ, State Key Lab Med Chem Biol, Inst Polymer Chem, Tianjin 300071, Peoples R China
[5] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[6] Diag Biotech Co Ltd, 3 Hengda Rd, Nanjing 210038, Jiangsu, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 93期
基金：
中国国家自然科学基金;
关键词：
POLYION COMPLEX MICELLES; DRUG-DELIVERY; ENZYME; VACCINES; ANTIBODY; THERAPY; SYSTEM;
D O I：
10.1039/c6cc05099a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient strategy for the intracellular delivery of proteins was developed based on assembling proteins with a self-crosslinkable polymer. Such a disulfide-crosslinking structure enhances the stability of the protein-polymer assembly, and also allows effective dissociation of the assembly in response to glutathione, which allows effective delivery of various proteins with high intracellular bioactivity.
引用
收藏
页码：13608 / 13611
页数：4
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