Synthesis and chromatographic study of methyl-2,3-O-isopropylidene-5-dimethyl-arsinoyl-β-D-ribofuranoside and methyl-2,3-O-isopropylidene-5-deoxy-5-dimethyl-thioarsinoyl-β-D-ribofuranoside

被引：6
|
作者：
Gyepes, Attila [1 ]
Schaffer, Richard [1 ]
Bajor, Gabor [2 ]
Woller, Agnes [1 ]
Fodor, Peter [1 ]
机构：
[1] Corvinus Univ Budapest, Dept Appl Chem, H-1114 Budapest, Hungary
[2] Budapest Univ Technol & Econ, Dept Inorgan Chem, H-1111 Budapest, Hungary
来源：
POLYHEDRON | 2008年 / 27卷 / 12期
关键词：
arsenosugars; methyl-2,3-O-isopropylidene-5-dimethyl-arsinoyl-beta-D-ribofuranoside; methyl-2,3-O-isopropylidene-5-deoxy-5-dimethyl-thioarsinoyl-beta-D-ribofuranoside; gas chromatography; thin-layer chromatography; trimethylsilylation;
D O I：
10.1016/j.poly.2008.04.049
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis of two riboside-containing arsenic compounds, methyl-2,3-O-isopropylidene-5-dimethylarsinoyl-beta-D-ribofuranoside and methyl-2,3-O-isopropylidene-5-deoxy-5-dimethyl-thioarsinoyl-beta-D-ribofuranoside is presented in this paper. Intermediates and final products of the synthesis were examined by gas chromatography and thin layer chromatography. The purity of the products was assessed by NMR spectroscopy. Trimethylsilylation was used to volatilise sugar compounds and thus use of the costly HPLC-MS technique was avoided. The results affirmed the presence of tautomers in case of arsenosugars. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2655 / 2661
页数：7
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