Depression and anxiety symptoms among patients receiving maintenance hemodialysis: a single center cross-sectional study

Background: To investigate depression and anxiety and related factors among patients receiving maintenance hemodialysis (MHD). Methods: This cross-sectional study included patients underwent MHD in 3/2022 at Jinshan Hospital affiliated to Fudan University. Depression and anxiety levels of patients were assessed using Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), respectively. SF-36 was used to assess patients' quality of life. Multiple linear regression analysis was used to determine the variables associated with the scores of BDI/BAI. Results: A total of 103 patients were included, 71 cases (68.93%) and 38 cases (36.89%) with depression and anxiety, respectively. The scores of almost all domains of the SF-36 showed a declining trend with increasing depression or anxiety among patients on MHD. Higher Charlson Comorbidity Index (CCI) (beta=0.066, 95%CI: 0.016-0.116, P = 0.010), lower educational status (beta = - 0.139, 95%CI: - 0.243- -0.036, P = 0.009), and number of oral medications (beta=0.177, 95%CI: 0.031-0.324, P = 0.018) were significantly associated with higher BDI scores. Longer dialysis duration (beta=0.098, 95%CI: 0.003-0.193, P = 0.044) and number of oral medications (beta=4.714, 95%CI: 1.837-7.590, P = 0.002) were significantly associated with higher BAI scores. Conclusions: Depression and anxiety may be likely to occur among patients undergoing MHD and impact their quality of life. Higher CCI, lower educational status and usage of multiple oral medications may be associated with depression, whereas longer dialysis duration and multiple oral medications may be associated with anxiety in MHD patients.