A method to estimate dispersion in sampling catheters and to calculate dispersion-free blood time-activity curves

被引:24
|
作者
Munk, Ole Lajord [1 ]
Keiding, Susanne [1 ,2 ]
Bass, Ludvik [3 ]
机构
[1] Aarhus Univ Hosp, PET Ctr, DK-8000 Aarhus, Denmark
[2] Aarhus Univ Hosp, Dept Med 5, DK-8000 Aarhus, Denmark
[3] Univ Queensland, Dept Math, Brisbane, Qld 4072, Australia
关键词
blood sampling; input function; dispersion; kinetic modeling; catheter;
D O I
10.1118/1.2948391
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The authors developed a transmission-dispersion model to estimate dispersion in blood sampling systems and to calculate dispersion-free input functions needed for kinetic analysis. Transport of molecules through catheters was considered in two parts: a central part with convective transmission of molecules and a stagnant layer that molecules may enter and leave. The authors measured dispersion caused by automatic and manual blood sampling using three PET tracers that distribute differently in blood ((CO)-O-15, (H2O)-O-15, and C-11-methylglucose). For manual sampling, dispersion was negligible. For the automated sampling procedure, characteristic parameters were calibrated for each tracer, and subsequently used in calculating dispersion-free input functions following real bolus injections. This led to shapes of dispersion-free input functions C-i(t) that had sharper peaks than the measured C-o(t), and the authors quantified the effect of correcting for dispersion before kinetic modeling. The transmission-dispersion model quantitatively takes apart effects of transmission and dispersion, it has transparent noise properties associated with each component, and it does not require deconvolution to calculate dispersion-free input functions. Once characteristic parameters are estimated, input functions can be corrected before applying kinetic models. This allows bias-free estimation of kinetic parameters such as blood flow. (c) 2008 American Association of Physicists in Medicine.
引用
收藏
页码:3471 / 3481
页数:11
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