Association between Long-Term Exposure to Traffic-Related Air Pollution and Subclinical Atherosclerosis: The REGICOR Study

被引:45
|
作者
Rivera, Marcela [1 ,2 ,3 ,4 ]
Basagana, Xavier [1 ,2 ]
Aguilera, Inmaculada [1 ,2 ]
Foraster, Maria [1 ,2 ,3 ]
Agis, David [1 ,2 ]
de Groot, Eric [5 ]
Perez, Laura [6 ,7 ]
Mendez, Michelle A. [8 ]
Bouso, Laura [1 ]
Targa, Jaume [9 ]
Ramos, Rafael [10 ,11 ]
Sala, Joan [12 ]
Marrugat, Jaume [13 ]
Elosua, Roberto [13 ]
Kunzli, Nino [6 ,7 ]
机构
[1] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
[2] Hosp Mar Res Inst IMIM, Barcelona, Spain
[3] Univ Pompeu Fabra, Barcelona, Spain
[4] Univ Montreal Hosp Res Ctr CRCHUM, Montreal, PQ H2W 1V1, Canada
[5] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands
[6] Swiss Trop & Publ Hlth Inst, Basel, Switzerland
[7] Univ Basel, Basel, Switzerland
[8] Univ N Carolina, Chapel Hill, NC USA
[9] 4sfera Innova, Girona, Spain
[10] Catalan Inst Hlth, Jordi Gol Inst Primary Care Res IDIAP Jordi Gol, Res Unit, Catalunya, Spain
[11] Univ Girona, Sch Med, Dept Med Sci, Girona, Spain
[12] Hosp Univ Josep Trueta, Inst Catala Salut, Serv Cardiol, Girona, Spain
[13] Hosp Mar Res Inst IMIM, Grp Epidemiol & Genet Cardiovasc, Barcelona, Spain
关键词
ankle-brachial index; average daily traffic; cardiovascular disease; exposure assessment; exposure to tailpipe emissions; intima media thickness; land use regression model; Mediterranean diet; nitrogen dioxide; INTIMA-MEDIA THICKNESS; ANKLE-BRACHIAL INDEX; PARTICULATE MATTER; CARDIOPULMONARY MORTALITY; CARDIOVASCULAR-DISEASE; RESIDENTIAL EXPOSURE; NITROGEN-DIOXIDE; PREVALENCE; OBESITY; METAANALYSIS;
D O I
10.1289/ehp.1205146
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
BACKGROUND: Epidemiological evidence of the effects of long-term exposure to air pollution on the chronic processes of atherogenesis is limited. OBJECTIVE: We investigated the association of long-term exposure to traffic-related air pollution with subclinical atherosclerosis, measured by carotid intima media thickness (IMT) and ankle-brachial index (ABI). METHODS: We performed a cross-sectional analysis using data collected during the reexamination (2007-2010) of 2,780 participants in the REGICOR (Registre Gironi del Cor: the Gerona Heart Register) study, a population-based prospective cohort in Girona, Spain. Long-term exposure across residences was calculated as the last 10 years' time-weighted average of residential nitrogen dioxide (NO2) estimates (based on a local-scale land-use regression model), traffic intensity in the nearest street, and traffic intensity in a 100 m buffer. Associations with IMT and ABI were estimated using linear regression and multinomial logistic regression, respectively, controlling for sex, age, smoking status, education, marital status, and several other potential confounders or intermediates. RESULTS: Exposure contrasts between the 5th and 95th percentiles for NO2 (25 mu g/m(3)), traffic intensity in the nearest street (15,000 vehicles/day), and traffic load within 100 m (7,200,000 vehicle-m/day) were associated with differences of 0.56% (95% CI: -1.5, 2.6%), 2.32% (95% CI: 0.48, 4.17%), and 1.91% (95% CI: -0.24, 4.06) percent difference in IMT, respectively. Exposures were positively associated with an ABI of > 1.3, but not an ABI of < 0.9. Stronger associations were observed among those with a high level of education and in men >= 60 years of age. CONCLUSIONS: Long-term traffic-related exposures were associated with subclinical markers of atherosclerosis. Prospective studies are needed to confirm associations and further examine differences among population subgroups.
引用
收藏
页码:223 / 230
页数:8
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