Association of Slow Acetylation Profile of NAT2 with Breast and Gastric Cancer Risk in Brazil

被引：0
|
作者：
Fernandes, Marianne Rodrigues [1 ,2 ]
De Carvalho, Darlen Cardoso [1 ,2 ]
Campos Ribeiro Dos Santos, Andrea Kelly [1 ,2 ]
Batista Dos Santos, Sidney Emanuel [1 ,2 ]
De Assumpcao, Paulo Pimentel [1 ,3 ]
Rodriguez Burbano, Rommel Mario [1 ,4 ]
Carneiro Dos Santos, Ney Pereira [1 ,2 ]
机构：
[1] Fed Univ Para, Oncol Res Ctr, BR-66059 Belem, Para, Brazil
[2] Fed Univ Para, Inst Biol Sci, Lab Human & Med Genet, BR-66059 Belem, Para, Brazil
[3] Fed Univ Para, Joao de Barros Barreto Univ Hosp, BR-66059 Belem, Para, Brazil
[4] Fed Univ Para, Inst Biol Sci, Lab Human Cytogenet, BR-66059 Belem, Para, Brazil
来源：
ANTICANCER RESEARCH | 2013年 / 33卷 / 09期
关键词：
NAT2; cancer susceptibility; SNP; IAM; breast cancer; gastric cancer; N-ACETYLTRANSFERASE; 2; GENETIC POLYMORPHISMS; PROSTATE-CANCER; SUSCEPTIBILITY; GENOTYPE; COMBINATION; METABOLISM; VARIANTS; ANCESTRY; SMOKING;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The N-acetyltransferase 2 (NAT2) gene is a marker for the study of interindividual susceptibility to developing neoplasias. The purpose of this study was to verify a possible association between single nucleotide polymomorphisms (SNPs) of NAT2 and the susceptibility to gastric cancer (GC) and breast cancer (BC) in patients from the North region of Brazil. Materials and Methods: Five SNPs of the NAT2 gene were investigated by direct sequencing. Ancestry was estimated by analysis of a panel with 48 ancestry-informative markers (AIM). Results: Individuals with slow acetylation profile had an increased risk of developing neoplasias up to three times when compared to controls. Conclusion: In this study, slow acetylation profile was found to strongly influence susceptibility to GC and BC.
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收藏
页码：3683 / 3689
页数：7
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