A high-fat diet is deleterious to mice under glycolysis restriction

被引：2

作者：

Hao, Yilin ^{[1
]}

Tsuruda, Toshihiro ^{[1
]}

Sekita-Hatakeyama, Yoko ^{[1
]}

Sakamoto, Sumiharu ^{[1
]}

Kitamura, Kazuo ^{[1
]}

机构：

[1] Univ Miyazaki, Dept Internal Med Circulatory & Body Fluid Regula, Fac Med, 5200 Kihara, Kiyotake, Miyazaki 8891692, Japan

来源：

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM | 2018年 / 43卷 / 04期

关键词：

low-carbohydrate; ketoacidosis; dehydration; LOW-CARBOHYDRATE DIETS; KETOGENIC DIET; CARDIOVASCULAR-DISEASE; HIGH-PROTEIN; GLUCOSE; LIPIDS; BRAIN; 2-DEOXY-D-GLUCOSE; BEHAVIOR; TISSUES;

D O I：

10.1139/apnm-2017-0506

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

It is debated whether carbohydrate restriction has metabolic advantage for its variable weight loss. Five-week-old male mice fed a high-fat diet and receiving a glycolytic inhibitor, 2-deoxyglucose, died within 9 days. They exhibited greater decreases in rectal temperature, appetite, and decline in body weight accompanied by increasing total cholesterol level than the other groups. This study suggests that carbohydrate is necessary for adequate physical and metabolic performance when lipid-rich diet is loaded.

引用

页码：419 / 422

页数：4

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