O-Glycosylation of Ligand-binding and Hinge Regions of Notch Extracellular Domain are Pivotal to Full Notch Activation

被引:0
|
作者
Rana, Nadia A. [1 ]
Nita-Lazar, Aleksandra [2 ]
Takeuchi, Hideyuki [1 ]
Tan, Eugene [1 ]
Haltiwanger, Robert S. [1 ]
机构
[1] SUNY Stony Brook, Stony Brook, NY 11794 USA
[2] MIT, Cambridge, MA 02139 USA
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
193
引用
收藏
页码:987 / 988
页数:2
相关论文
共 25 条
  • [1] Fringe Benefits: Analysis of O-Glycosylation and Fringe Elongation on the Extracellular Domain of Drosophila Notch
    Rana, Nadia A.
    Xu, Min Li
    Moss, Hillary
    Rab, Ahmed
    Leonardi, Jessica
    Jafar-Nejad, Hamed
    Haltiwanger, Robert S.
    [J]. GLYCOBIOLOGY, 2010, 20 (11) : 1486 - 1486
  • [2] Fringe benefits: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors
    Rana, Nadia A.
    Haltiwanger, Robert S.
    [J]. CURRENT OPINION IN STRUCTURAL BIOLOGY, 2011, 21 (05) : 583 - 589
  • [3] Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions
    Saiki, Wataru
    Ma, Chenyu
    Okajima, Tetsuya
    Takeuchi, Hideyuki
    [J]. BIOMOLECULES, 2021, 11 (02) : 1 - 20
  • [4] An O-fucose site in the ligand binding domain inhibits Notch activation
    Lei, L
    Xu, AG
    Panin, VM
    Irvine, KD
    [J]. DEVELOPMENT, 2003, 130 (26): : 6411 - 6421
  • [5] Mice with Notch1 lacking O-fucose in the ligand-binding domain are viable and fertile
    Ge, CH
    Stanley, P
    [J]. GLYCOBIOLOGY, 2005, 15 (11) : 1220 - 1221
  • [6] Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties
    Timothy Sargis
    Seock-Won Youn
    Krishna Thakkar
    L. A. Naiche
    Na Yoon Paik
    Kostandin V. Pajcini
    Jan K. Kitajewski
    [J]. Angiogenesis, 2023, 26 : 249 - 263
  • [7] Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties
    Sargis, Timothy
    Youn, Seock-Won
    Thakkar, Krishna
    Naiche, L. A.
    Paik, Na Yoon
    Pajcini, Kostandin, V
    Kitajewski, Jan K.
    [J]. ANGIOGENESIS, 2023, 26 (02) : 249 - 263
  • [8] NONCONTIGUOUS REGIONS IN THE EXTRACELLULAR DOMAIN OF EGF RECEPTOR DEFINE LIGAND-BINDING SPECIFICITY
    LAX, I
    FISCHER, R
    NG, C
    SEGRE, J
    ULLRICH, A
    GIVOL, D
    SCHLESSINGER, J
    [J]. CELL REGULATION, 1991, 2 (05): : 337 - 345
  • [9] Targeting Specific Regions of the Notch3 Ligand-Binding Domain Induces Apoptosis and Inhibits Tumor Growth in Lung Cancer
    Lin, Luping
    Mernaugh, Ray
    Yi, Fuming
    Blum, David
    Carbone, David P.
    Dang, Thao P.
    [J]. CANCER RESEARCH, 2010, 70 (02) : 632 - 638
  • [10] The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development
    Ge, Changhui
    Stanley, Pamela
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (05) : 1539 - 1544