The BDNF Val66Met polymorphism and smoking

被引：28
|
作者：
Montag, Christian [1 ]
Basten, Ulrike [2 ]
Stelzel, Christine [2 ]
Fiebach, Christian J. [2 ]
Reuter, Martin
机构：
[1] Univ Bonn, Dept Psychol, D-53111 Bonn, Germany
[2] Heidelberg Univ, Dept Psychol Neurol & Neuroradiol, D-6900 Heidelberg, Germany
来源：
NEUROSCIENCE LETTERS | 2008年 / 442卷 / 01期
关键词：
BDNF Val66Met; smoking; nicotine dependence; addiction;
D O I：
10.1016/j.neulet.2008.06.064
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Although the brain derived neurotrophic factor (BDNF) has been mainly investigated in the context of depression and anxiety disorders, several studies also suggest an association between BDNF and smoking. BDNF represents a protein which crucially influences several processes in the cell ranging from growth to apoptosis. A functional variant of the BDNF gene - the BDNF Val66Met polymorphism - is one of the main targets in BDNF research because of its influence on BDNF secretion. Recently an association between the 66Met allele and smoking has been reported in a sample of 320 Caucasians. The aim of the present study was to replicate this association in a sample nearly twice as large consisting of N = 614 German Caucasian participants. A link between smoking and the BDNF Val66Met polymorphism could not be found in our data. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：30 / 33
页数：4
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