Synthesis of Antioxidants for Prevention of Age-Related Macular Degeneration

被引：35
|
作者：
Joshi, Dharati [1 ]
Field, James [1 ]
Murphy, John [1 ]
Abdelrahim, Mohammed [1 ]
Schoenherr, Heike [2 ]
Sparrow, Janet R. [2 ]
Ellestad, George [1 ]
Nakanishi, Koji [1 ]
Zask, Arie [1 ]
机构：
[1] Columbia Univ, Dept Chem, New York, NY 10027 USA
[2] Columbia Univ, Dept Ophthalmol, New York, NY 10032 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 03期
基金：
美国国家卫生研究院;
关键词：
LIGHT-INDUCED DAMAGE; LIPOFUSCIN FLUOROPHORE; EPITHELIAL-CELLS; PIGMENT A2-E; A2E; ANALOGS;
D O I：
10.1021/np300769c
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Photooxidation of A2E may be involved in diseases of the macula, and antioxidants could serve as therapeutic agents for these diseases. Inhibitors of A2E photooxidation were prepared by Mannich reaction of the antioxidant quercetin. These compounds contain water-solubilizing amine groups, and several were more potent inhibitors of A2E photooxidation than quercetin.
引用
收藏
页码：450 / 454
页数：5
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