The neurosecretory system is hypertrophied in senescence-accelerated mice

被引：1
|
作者：
Crespo, D [1 ]
Megias, M [1 ]
Fernandez-Viadero, C [1 ]
Alonso, L [1 ]
Verduga, R [1 ]
机构：
[1] Univ Cantabria, Dept Anat & Cell Biol, Biogerontol Unit, Fac Med, Santander 39011, Spain
来源：
REJUVENATION RESEARCH | 2006年 / 9卷 / 02期
关键词：
D O I：
10.1089/rej.2006.9.297
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The hypothalamic supraoptic and paraventricular nuclei form the neurosecretory system and synthesize the neurohormones oxytocin and arginine-vasopressin. The senescence-accelerated mouse is a model of rapid aging that displays senile amyloidosis and memory problems. This paper presents the characterization of the neurosecretory system and describes the presence of a bilateral constant cluster of neurosecretory neurons in these mice. The stereologic analysis revealed that these groups contain 197 +/- 18 cells (87% synthesize arginine-vasopressin and 13% oxytocin). The presence of these clusters of neurosecretory neurons suggests that these mice could present greater neurohormone synthesis, increasing the deleterious effects of accelerated aging in this strain.
引用
收藏
页码：297 / 301
页数：5
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