Synthesis of sterically high demanding alpha-alkylated amino acids via Claisen rearrangement of chelated enolates

被引：53

作者：

Kazmaier, U

Maier, S

机构：

[1] Organ.-Chemisches Inst. der Univ., D-69120 Heidelberg

来源：

TETRAHEDRON | 1996年 / 52卷 / 03期

关键词：

D O I：

10.1016/0040-4020(95)00946-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ester enolate Claisen rearrangement of chelated N-protected amino acid allylic esters 1 and 4 results in the formation of alpha-alkylated gamma,delta-unsaturated amino acids 3 and 5 in good yields and in a highly diastereoselective fashion.

引用

页码：941 / 954

页数：14

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