ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora

被引：6
|
作者：
Wang Weiguang [1 ,2 ]
Wu Haiyan [1 ]
Du Xue [1 ]
Yan Juming [1 ]
Li Yan [1 ]
Pu Jianxin [1 ]
Sun Handong [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunan, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Kunming 650201, Yunan, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2012年 / 30卷 / 06期
基金：
中国国家自然科学基金;
关键词：
ent-Kaurane diterpenoid; Isodon; structure elucidation; cytotoxicity;
D O I：
10.1002/cjoc.201100653
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Four new ent-kaurane diterpenoids, 6 beta,13a,15 beta-trihydroxy-16-ene-3a,20-epoxy-ent-kaur-1,7-dione (1), 6-hydroxy-3a,20-epoxy-5(6)-ene-ent-kaur-1,7,15-trione (2), 6-hydroxy-15 beta-acetoxy-3a,20-epoxy-16 beta,17-epoxy-5(6)-ene-ent-kaur-1,7-dione (3), 3a,17-dihydroxy-15(16)-ene-ent-kaur-7-one (4), along with four known compounds 58 were isolated from the leaves of Isodon eriocalyx var. laxiflora. The structures were elucidated by extensive spectroscopic methods (IR, UV, MS and NMR). The cytotoxic activities of these compounds were evaluated by MTT assay. Compound 8 showed moderate inhibitory effects on HL-60, SMMC-7721, MCF-7 and SW-480 cell lines.
引用
收藏
页码：1226 / 1230
页数：5
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