Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology

被引：483
|
作者：
Hallberg, Bengt [1 ]
Palmer, Ruth H. [1 ]
机构：
[1] Umea Univ, Dept Mol Biol, S-90187 Umea, Sweden
来源：
NATURE REVIEWS CANCER | 2013年 / 13卷 / 10期
基金：
瑞典研究理事会;
关键词：
ANAPLASTIC LYMPHOMA KINASE; LARGE-CELL LYMPHOMA; INFLAMMATORY MYOFIBROBLASTIC TUMOR; NPM-ALK; LUNG-CANCER; MOLECULAR CHARACTERIZATION; DOWN-REGULATION; TRUNCATED FORM; GROWTH-FACTOR; FUSION GENE;
D O I：
10.1038/nrc3580
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer (NSCLC). The common activation of ALK has led to the use of the ALK tyrosine kinase inhibitor (TKI) crizotinib in a range of patient populations and to the rapid development of second-generation drugs targeting ALK. In this Review, we discuss our current understanding of ALK function in human cancer and the implications for tumour treatment.
引用
收藏
页码：685 / 700
页数：16
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