Amphiphilic poly(ethylene glycol)-b-poly(ethylene brassylate) copolymers: One-pot synthesis, self-assembly, and controlled drug release

被引：30
|
作者：
Chen, Jiu-Cun [1 ,2 ,3 ]
Li, Jun-Zhi [1 ,3 ]
Liu, Jian-Hua [1 ,3 ]
Xu, Li-Qun [1 ,3 ]
机构：
[1] Southwest Univ, Inst Clean Energy & Adv Mat, Chongqing 400715, Peoples R China
[2] Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
[3] Chongqing Key Lab Adv Mat & Technol Clean Energie, Chongqing 400715, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2015年 / 26卷 / 10期
关键词：
Poly(ethylene brassylate); Self-assembly; Nanoparticles; Controlled drug release; RING-OPENING POLYMERIZATION; DELIVERY; MICELLES; VESICLES;
D O I：
10.1016/j.cclet.2015.05.050
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A set of amphiphilic poly( ethylene glycol)-b-poly(ethylene brassylate) (PEG-b-PEB) copolymers based on the PEB hydrophobic block was first synthesized by ring-opening polymerization of ethylene brassylate with an organic catalyst. The EB/PEG molar ratios and reaction times were adjusted to achieve different chain lengths of PEB. Block copolymers that were characterized by H-1 NMR and GPC could self-assemble into multimorphological aggregates in aqueous solution, which were characterized by DLS and TEM. The hydrophobic doxorubicin (DOX) was chosen as a drug model and successfully encapsulated into the nanoparticles. The release kinetics of DOX were investigated. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1319 / 1321
页数：3
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