Bioassay-guided isolation, identification, and quantification of the estrogen-like constituent from PCSPES

被引：0

作者：

Sang, SM ^{[1
]}

Liu, ZH ^{[1
]}

Rosen, RT ^{[1
]}

Ho, CT ^{[1
]}

机构：

[1] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Piscataway, NJ 08854 USA

来源：

HERBS: CHALLENGES IN CHEMISTRY AND BIOLOGY | 2006年 / 925卷

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The herbal mixture PC SPES, a dietary supplement for patients with prostate cancer, has been proved to have estrogenic activity in clinical trials. To determine the active components in PC SPES for estrogenic activity; a bioassay-guided fractionation of PC SPES using a functional estrogen receptor (ER) assay led to the isolation and identification of the most active constituent, ethinyl estrodiol, together with two flavonones, neobaicalein and tenaxin I. The isolation, identification and quantification of ethinyl estrodiol are discussed.

引用

页码：117 / 125

页数：9

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