Anti-microbial compounds targeting the alternative thymidylate synthase ThyX

被引:0
|
作者
Myllykallio, H. [1 ]
Djaout, K. [1 ]
Skouloubris, S. [1 ]
Liebl, U. [1 ]
机构
[1] Ecole Polytech, Lab Opt & Biosci, Palaiseau, France
关键词
antibacterial; microbiology; Thymidylate biosynthesis cycle; MECHANISM;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
WED-104
引用
收藏
页码:651 / 652
页数:2
相关论文
共 50 条
  • [1] Mechanism of Naphthoquinone Selectivity of Thymidylate Synthase ThyX
    Myllykallio, Hannu
    Becker, Hubert F.
    Aleksandrov, Alexey
    BIOPHYSICAL JOURNAL, 2020, 119 (12) : 2508 - 2516
  • [2] Mechanistic and structural basis for inhibition of thymidylate synthase ThyX
    Basta, Tamara
    Boum, Yap
    Briffotaux, Julien
    Becker, Hubert F.
    Lamarre-Jouenne, Isabelle
    Lambry, Jean-Christophe
    Skouloubris, Stephane
    Liebl, Ursula
    Graille, Marc
    van Tilbeurgh, Herman
    Myllykallio, Hannu
    OPEN BIOLOGY, 2012, 2
  • [3] Thermal stability and binding energetics of thymidylate synthase ThyX
    Krumova, Sashka
    Todinova, Svetla
    Tileva, Milena
    Bouzhir-Sima, Latifa
    Vos, Marten H.
    Liebl, Ursula
    Taneva, Stefka G.
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 91 : 560 - 567
  • [4] Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones
    Skouloubris, Stephane
    Djaout, Kamel
    Lamarre, Isabelle
    Lambry, Jean-Christophe
    Anger, Karine
    Briffotaux, Julien
    Liebl, Ursula
    de Reuse, Hilde
    Myllykallio, Hannu
    OPEN BIOLOGY, 2015, 5 (06):
  • [5] Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis
    Kamel Djaout
    Vinayak Singh
    Yap Boum
    Victoria Katawera
    Hubert F. Becker
    Natassja G. Bush
    Stephen J. Hearnshaw
    Jennifer E. Pritchard
    Pauline Bourbon
    Peter B. Madrid
    Anthony Maxwell
    Valerie Mizrahi
    Hannu Myllykallio
    Sean Ekins
    Scientific Reports, 6
  • [6] Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis
    Djaout, Kamel
    Singh, Vinayak
    Boum, Yap
    Katawera, Victoria
    Becker, Hubert F.
    Bush, Natassja G.
    Hearnshaw, Stephen J.
    Pritchard, Jennifer E.
    Bourbon, Pauline
    Madrid, Peter B.
    Maxwell, Anthony
    Mizrahi, Valerie
    Myllykallio, Hannu
    Ekins, Sean
    SCIENTIFIC REPORTS, 2016, 6
  • [7] Insight into the catalytic mechanism of thymidylate synthase ThyX of Campylobacter jejuni
    Sodolescu, S. A.
    Graziani, S.
    Boum, Y.
    Myllykallio, H.
    Liebl, U.
    ZOONOSES AND PUBLIC HEALTH, 2007, 54 : 55 - 55
  • [8] The gene encoding the alternative thymidylate synthase ThyX is regulated by sigma factor SigB in Corynebacterium glutamicum ATCC 13032
    Cho, Sukhyeong
    Yang, Seokbin
    Rhie, Hogun
    FEMS MICROBIOLOGY LETTERS, 2012, 328 (02) : 157 - 165
  • [9] Alternative thymidylate synthase, ThyX, involved in Corynebacterium glutamicum ATCC 13032 survival during stationary growth phase
    Park, Mijeong
    Cho, Sukhyeong
    Lee, Hosa
    Sibley, Carol Hopkins
    Rhie, Hogun
    FEMS MICROBIOLOGY LETTERS, 2010, 307 (02) : 128 - 134
  • [10] Weak acids as an alternative anti-microbial therapy
    Kundukad, Binu
    Udayakumar, Gayathri
    Grela, Erin
    Kaur, Dhamanpreet
    Rice, Scott A.
    Kjelleberg, Staffan
    Doyle, Patrick S.
    BIOFILM, 2020, 2