The Janus face of caffeine

被引：35
|
作者：
Porciuncula, Lisiane O. [1 ]
Sallaberry, Cassia [1 ]
Mioranzza, Sabrina [1 ]
Botton, Paulo Henrique S. [1 ]
Rosemberg, Denis B. [1 ,2 ]
机构：
[1] Univ Fed Rio Grande do Sul, Dept Bioquim ICBS, Lab Estudos Sistema Purinerg, Porto Alegre, RS, Brazil
[2] Univ Comunitaria Regiao Chapeco, Lab Genet & Ecotoxicol Mol, Programa Posgrad Ciencias Ambientais, Area Ciencias Exatas & Ambientais, BR-89809000 Chapeco, SC, Brazil
来源：
NEUROCHEMISTRY INTERNATIONAL | 2013年 / 63卷 / 06期
关键词：
Caffeine; Adenosine; Brain development; Learning and memory; ADENOSINE A(1) RECEPTOR; METABOTROPIC GLUTAMATE RECEPTORS; PONTINE RETICULAR-FORMATION; LONG-TERM POTENTIATION; OPEN-FIELD BEHAVIOR; A(2A) RECEPTORS; GENE-EXPRESSION; LOCOMOTOR-ACTIVITY; RAT-BRAIN; ACETYLCHOLINE-RELEASE;
D O I：
10.1016/j.neuint.2013.09.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Caffeine is certainly the psychostimulant substance most consumed worldwide. Over the past years, chronic consumption of caffeine has been associated with prevention of cognitive decline associated to aging and mnemonic deficits of brain disorders. While its preventive effects have been reported extensively, the cognitive enhancer properties of caffeine are relatively under debate. Surprisingly, there are scarce detailed ontogenetic studies focusing on neurochemical parameters related to the effects of caffeine during prenatal and earlier postnatal periods. Furthermore, despite the large number of epidemiological studies, it remains unclear how safe is caffeine consumption during pregnancy and brain development. Thus, the purpose of this article is to review what is currently known about the actions of caffeine intake on neurobehavioral and adenosinergic system during brain development. We also reviewed other neurochemical systems affected by caffeine, but not only during brain development. Besides, some recent epidemiological studies were also outlined with the control of "pregnancy signal" as confounding variable. The idea is to tease out how studies on the impact of caffeine consumption during brain development deserve more attention and further investigation. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：594 / 609
页数：16
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