Glasshouse research was conducted to investigate the efficacy of herbicide safeners for improving creeping bentgrass (CBG) tolerance to various herbicides. CBG injury from amicarbazone (150 g ha(-1)), bispyribac-sodium (110 g ha(-1)), fenoxaprop-p-ethyl (35 g ha(-1)), imazapic (45 g ha(-1)), quinclorac (1,050 g ha(-1)), or topramezone (37 g ha(-1)) applied in combination with the herbicide safeners naphthalic anhydride or isoxadifen-ethyl was evaluated. These safeners reduced CBG injury from topramezone only. Topramezone was then applied in combination with naphthalic anhydride, isoxadifen-ethyl, cloquintocet-mexyl (cloquintocet), fenchlorazole-ethyl, mefenpyr-diethyl, and benoxacor. These experiments determined that CBG injury was lowest from topramezone in combination with cloquintocet. Additional experiments evaluated topramezone (37 g ha(-1)) with several rates of cloquintocet and determined that applications at >= 28 g ha(-1) reduced CBG injury similarly. Cloquintocet (28 g ha(-1)) increased topramezone I-50 values against CBG, but not large crabgrass or goosegrass. The cytochrome P450 (cP450) inhibitor malathion (1000 g ha(-1)) reduced topramezone I-50 values against CBG in one experimental run. Topramezone-cloquintocet combinations warrant further research in field settings.