Cloning and characterisation of the gene for the large subunit of the DNA primase from Drosophila melanogaster

被引：10
|
作者：
Huikeshoven, H [1 ]
Cotterill, S [1 ]
机构：
[1] Marie Curie Res Inst, Oxted RH8 0TL, England
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1999年 / 1445卷 / 03期
关键词：
primase; in situ localization; developmental expression; Dref; E2f;
D O I：
10.1016/S0167-4781(99)00063-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have cloned the gene for the large subunit of the DNA primase from Drosophila melanogaster, and mapped it to position 77b on chromosome 3. The central region of the protein shows high similarity with homologues from other species, but the N- and C-termini diverge. The protein is enriched in replicating tissues, and consistent with this the region upstream of the gene contains close matches to the sites of two transcription factors - Dref and E2f - which have been implicated in controlling proliferation-associated genes. (C) 1999 Elsevier Science B.V. All rights reserved.
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页码：359 / 362
页数：4
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