5-(4-fluorophenyl)-1,8-dimethyl-2-(p-toluoylaminomethyl)-2,3-dihydro-1H-1,4-benzodiazepine monohydrate

The title compound, N-{[5-(4-fluorophenyl)-1,8-dimethyl-2,3-dihydro-1H-1,4-benzodiazepin-2-yl]methyl}p-toluamide monohydrate, C26H26FN3O.H2O, a benzodiazepine derivative with kappa-opioid activity, crystallizes as a hydrate with two almost identical molecules in the asymmetric unit. The observed conformation, stabilized by two hydrogen bonds involving the H2O molecule, is common for the 2-(acylaminomethyl)benzodiazepines. Hydrogen bonds between H2O molecules and amidic O atoms link the non-equivalent molecules, with formation of endless chains in the a direction.