Immunohistochemical evaluation of insulin-like growth factor I receptor status in cervical cancer specimens

被引:0
|
作者
Kuramoto, Hiroyuki [1 ]
Hongo, Atsushi [1 ]
Liu, Yi-xuan [1 ]
Ojima, Yojiro [1 ]
Nakamura, Keiichiro [1 ]
Seki, Noriko [1 ]
Kodama, Junichi [1 ]
Hiramatsu, Yuji [1 ]
机构
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Obstet & Gynecol, Okayama 7008558, Japan
关键词
insulin-like growth factor I receptor; cervical cancer; human papillomavirus; tyrosil phosphorylation;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The insulin-like growth factor I receptor (IGF-IR) is exceptionally overexpressed in many cervical-cancer-derived cell lines. It is postulated that a decrease of p53 protein levels due to human papillomavirus (HPV) infection may contribute to the up-regulation of IGF-IR expression in cervical cancer cells because transcription of IGF-IR is strictly down-regulated by p53. To evaluate this fact in clinical cervical cancer specimens, we checked the expression levels and activated status of IGF-IR by immunohistochemistry. Formalin-fixed and paraffin-embedded specimens obtained by conization or hysterectomy were stained with anti-IGF-IR and with an antibody recognizing phosphorylated tyrosine at its c-terminus. The expression levels of IGF-IR were significantly high in cervical intraepithelial neoplasia (CIN) III and invasive cancer specimens. Phosphorylation of IGF-IR was promoted in all CIN and invasive cancer specimens, and its intensity was related to the promotion of lesions. Interestingly, IGF-IR overexpression was missing in the basal layer of CIN I and II lesions, whereas it was evenly distributed in CIN III and invasive cancer lesions. This IGF-IR overexpression pattern may be utilized in the diagnosis of HIV infection status in CIN lesions.
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页码:251 / 259
页数:9
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