Effect of the Mobile Phase Composition on Selectivity in Supercritical Fluid Chromatography in the Separation of Salbutamol Enantiomers

被引：4
|
作者：
Kostenko, M. O. [1 ,2 ]
Ustinovich, K. B. [1 ,2 ]
Pokrovskiy, O. I. [1 ,2 ]
Parenago, O. O. [1 ,2 ]
Bazarnova, N. G. [3 ]
Lunin, V. V. [1 ,2 ]
机构：
[1] Russian Acad Sci, Kurnakov Inst Gen & Inorgan Chem, Moscow 119991, Russia
[2] Moscow MV Lomonosov State Univ, Chem Dept, Moscow 119991, Russia
[3] Altai State Univ, Chem Dept, Barnaul 656049, Russia
来源：
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY B | 2018年 / 12卷 / 07期
基金：
俄罗斯科学基金会;
关键词：
salbutamol; enantiomers; supercritical fluid chromatography; polysaccharide-based chiral stationary phases; CARBON-DIOXIDE; ADSORPTION; ISOTHERMS; ADDITIVES; PRESSURE; METHANOL; SILICA;
D O I：
10.1134/S1990793118070059
中图分类号：
O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号：
070203 ; 070304 ; 081704 ; 1406 ;
摘要：
Three chiral chromatography stationary phases based on amylose and cellulose were tested for the supercritical fluid chromatography separation of antiasthmatic drug salbutamol enantiomers. A cellulose tris- 3-chloro-4-methylphenylcarbamate stationary phase provided the highest selectivity for this separation. The optimization of mobile phase composition allowed us to maximize the selectivity coefficient and to minimize the peak asymmetry factors. A successful salbutamol enantiomer separation is achieved at moderate modifier fraction (10-15 vol %) in the mobile phase on this column. Amine additives are necessary to suppress peak tailing. Among three tested amines isopropylamine gives the most symmetrical peaks along with the highest enantioselectivity.
引用
收藏
页码：1166 / 1175
页数：10
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