Larvicidal, antimycobacterial and antifungal compounds from the bark of the Peruvian plant Swartzia polyphylla DC

被引：27

作者：

Rojas, R

Bustamante, B

Ventosilla, P

Fernádez, I

Caviedes, L

Gilman, RH

Lock, O

Hammond, GB ^{[1
]}

机构：

[1] Univ Louisville, Dept Chem, Louisville, KY 40292 USA

[2] Univ Peruana Cayetano Heredia, Fac Ciencias & Filosofia, Dept Ciencias Farmaceut, Lima, Peru

[3] Univ Peruana Cayetano Heredia, Inst Med Trop Alexander Humboldt, Lima 100, Peru

[4] Univ Peruana Cayetano Heredia, Fac Ciencias & Filosofia, Dept Microbiol, Lima 100, Peru

[5] Johns Hopkins Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA

[6] Pontificia Univ Catolica Peru, Dept Quim, Lima 100, Peru

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 02期

关键词：

antimycobacterial; antifungal; biochanin A; dihydrobiochanin A; larvicidal; Swartzia polyphylla;

D O I：

10.1248/cpb.54.278

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 95% ethanol extract of the bark of Swartzia polyphylla DC (Fabaceae) possesses important larvicidal, antimycobacterial and antifungal activity in vitro. Bioassay-guided studies performed on the crude ethanol extract afforded T-cadinol as the larvicidal and anti-Mycobacterium tuberculosis principle, while the antifungal activity of the extract is due to the presence of the flavonoids biochanin A and dihydrobiochanin A.

引用

页码：278 / 279

页数：2

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