Cost-effectiveness of human papillomavirus vaccine in reducing the risk of cervical cancer in Ireland due to HPV types 16 and 18 using a transmission dynamic model

被引:36
|
作者
Usher, Cara [1 ]
Tilson, Lesley [1 ]
Olsen, Jens [2 ]
Jepsen, Martin [3 ]
Walsh, Cathal [1 ,4 ,5 ]
Barry, Michael [1 ]
机构
[1] St James Hosp, Natl Ctr Pharmacoecon, Dublin 8, Ireland
[2] Tech Univ Denmark, Ctr Appl Hlth Serv Res & Technol Assessment, DK-5000 Odense C, Denmark
[3] Statens Serum Inst, Dept Epidemiol, DK-2300 Copenhagen S, Denmark
[4] Univ Dublin Trinity Coll, Dept Stat, Dublin 2, Ireland
[5] Univ Coll Dublin, UCD Sch Publ Hlth & Populat Sci, Dublin 4, Ireland
关键词
HPV vaccination; Cost effectiveness; Decision maker;
D O I
10.1016/j.vaccine.2008.07.098
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We evaluated the cost-effectiveness of combining a cervical cancer screening programme with a national HPV vaccination programme compared to a screening programme alone to prevent cervical dysplasia and cervical cancer related to HPV types 16 and 18 in the Irish healthcare setting. The incremental cost effectiveness of vaccination strategies for 12-year-old females (base-case) and 12-26-year-old catch-up vaccination strategies were examined. The base-case incremental cost-effectiveness ratio was (sic)17,383/LYG. Using a probabilistic sensitivity analysis about the base-case, the 95% CI for cost per LYG was ((sic)3400 to E38,400). This suggests that vaccination against HPV types 16 and 18 would be cost-effective from the perspective of the Irish healthcare payer. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5654 / 5661
页数:8
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