Biokinetics and dose assessment after iodine intake in a thyroidectomised rat model

被引：2

作者：

Mezaguer-Lekouaghet, Meriem ^{[1
]}

Souidi, Maamar ^{[2
]}

Badreddine, Abdewahab ^{[1
]}

Blanchardon, Eric ^{[2
]}

Bertho, Jean-Marc ^{[2
]}

Benadjaoud, Mohamed Amine ^{[2
]}

Baz, Ahcene ^{[3
]}

Lounis-Mokrani, Zohra ^{[1
]}

机构：

[1] CRNA, Algiers, Algeria

[2] IRSN, Fontenay Aux Roses, France

[3] Ecole Normale Super Kouba ENS, Kouba, Algeria

来源：

JOURNAL OF RADIOLOGICAL PROTECTION | 2019年 / 39卷 / 01期

关键词：

iodine-131; biodistribution; biological half-life; thyroid; rat; ionizing radiation; EFFECTIVE HALF-LIFE; RODES SOFTWARE; CLEARANCE; THYROXINE; THERAPY; I-131; MICE;

D O I：

10.1088/1361-6498/aaf925

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Procedures using iodine-131 represent more than 90% of all therapies in nuclear medicine in Algeria. It is important to evaluate the long-term biological effects of iodine treatment on non-target organs to improve patient radiation protection. This experimental radiotoxicology study aims to determine the biokinetic models of iodine contamination. For this purpose, two Wistar rat models, with and without a thyroid, have been used to evaluate the biological half-life of iodine and then to perform a biodistribution study of iodine activity in 15 organs and tissues. For the most relevant organs, the respective absorbed doses have been calculated using RODES software.

引用

页码：292 / 308

页数：17

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