Robustness of signal transduction pathways

被引：21

作者：

Bluethgen, Nils ^{[1
,2
]}

Legewie, Stefan ^{[3
]}

机构：

[1] Charite, Inst Pathol, D-10117 Berlin, Germany

[2] Humboldt Univ, Inst Theoret Biol, D-10115 Berlin, Germany

[3] Inst Mol Biol, D-55128 Mainz, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2013年 / 70卷 / 13期

关键词：

Robustness; Feedback; Signal transduction; Adaptation; Sensitivity; Heterogeneity; MAPK; BMP; TO-CELL VARIABILITY; NEGATIVE FEEDBACK; QUANTITATIVE-ANALYSIS; PERFECT ADAPTATION; REGULATED KINASE; GENE-EXPRESSION; PROTEIN-LEVELS; FATE DECISION; LIVING CELLS; NETWORKS;

D O I：

10.1007/s00018-012-1162-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Signal transduction pathways transduce information about the outside of the cell to the nucleus, regulating gene expression and cell fate. To reliably inform the cell about its surroundings, information transfer has to be robust against typical perturbation that a cell experiences. Robustness of several mammalian signaling pathways has been studied recently by quantitative experimentation and using mathematical modeling. Here, we review these studies, and describe the emerging concepts of robustness and the underlying mechanisms.

引用

页码：2259 / 2269

页数：11

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