Differential modulatory effect of NGF on MHC class I and class II expression in spinal cord cells of EAE rats

Nerve growth factor (NGF) undergoes significant changes in the central nervous system (CNS) of patients affected by multiple sclerosis (MS) and of rats with experimental allergic encephalomyelitis (EAE). The major histocompatibility complex (MCH) class I and class II antigens are molecules that play a pivotal role in these neuro-inflammatory disorders. The aim of this study was to investigate the role of NGF oil MCH class I and class It antigens in spinal cords cells of EAE rats. It was found that the administration of NGF in EAE rats enhances MHC-1, lFN-gamma receptor and interferon regulatory factor-1 expression on the neurons but not in the glial cells, while NGF decreased MHC class II antigen in the glial cells. NGF administration into the brain of EAE rats has no effect on TNF-alpha expression. The present findings suggest that NGF may have a regulatory function in spinal cord cells during tissue inflammation. (C) 2005 Elsevier B.V. All rights reserved.