Synthesis and structure-activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs

被引：7

作者：

Garcia-Rodriguez, Jose ^{[1
]}

Mendiratta, Saurabh ^{[2
]}

White, Michael A. ^{[2
]}

Xie, Xiao-Song ^{[3
]}

De Brabander, Jef K. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Eugene McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 20期

关键词：

V-ATPase; Antiviral; Anticancer; Benzolactone; Salicylihalamide; FORMAL TOTAL-SYNTHESIS; VACUOLAR H+-ATPASE; SALICYLIHALAMIDE-A; POTENT SALICYLIHALAMIDE; 1,3-DIOL ACETONIDES; CANCER; (-)-SALICYLIHALAMIDE-A; IDENTIFICATION; MECHANISM; INFECTION;

D O I：

10.1016/j.bmcl.2015.09.021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient total synthesis of the potent V-ATPase inhibitor saliphenylhalamide (SaliPhe), a synthetic variant of the natural product salicylihalamide A (SaliA), has been accomplished aimed at facilitating the development of SaliPhe as an anticancer and antiviral agent. This new approach enabled facile access to derivatives for structure-activity relationship studies, leading to simplified analogs that maintain SaliPhe's biological properties. These studies will provide a solid foundation for the continued evaluation of SaliPhe and analogs as potential anticancer and antiviral agents. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：4393 / 4398

页数：6

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