A Journey through the Cytoskeleton with Protein Kinase CK2

被引：24
|
作者：
D'Amore, Claudio [1 ]
Salizzato, Valentina [1 ,2 ]
Borgo, Christian [1 ]
Cesaro, Luca [1 ]
Pinna, Lorenzo A. [1 ,2 ]
Salvi, Mauro [1 ]
机构：
[1] Univ Padua, Dept Biomed Sci, Via U Bassi 58-B, Padua, Italy
[2] CNR, Inst Neurosci, Via U Bassi 58-B, Padua, Italy
来源：
CURRENT PROTEIN & PEPTIDE SCIENCE | 2019年 / 20卷 / 06期
关键词：
Post-translational modifications; actin; tubulin; septin; casein kinase 2; acidic phosphorylation; INTERMEDIATE-FILAMENT PROTEINS; INTERKINETIC NUCLEAR MIGRATION; CK2-ALPHA INHIBITS MIGRATION; POSTTRANSLATIONAL MODIFICATIONS; PHOSPHORYLATION EVENTS; ACTIN POLYMERIZATION; DYNAMIC INSTABILITY; CATALYTIC SUBUNITS; STABLE KNOCKDOWN; CELL MORPHOLOGY;
D O I：
10.2174/1389203720666190119124846
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Substrate pleiotropicity, a very acidic phosphorylation consensus sequence, and an apparent uncontrolled activity, are the main features of CK2, a Ser/Thr protein kinase that is required for a plethora of cell functions. Not surprisingly, CK2 appears to affect cytoskeletal structures and correlated functions such as cell shape, mechanical integrity, cell movement and division. This review outlines our current knowledge of how CK2 regulates cytoskeletal structures, and discusses involved pathways and molecular mechanisms.
引用
收藏
页码：547 / 562
页数：16
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