COMPARISON OF ROBUST CRITERIA FOR D-OPTIMAL DESIGNS

被引：11

作者：

Foo, Lee Kien ^{[1
]}

McGree, James ^{[2
]}

Eccleston, John ^{[3
]}

Duffull, Stephen ^{[1
]}

机构：

[1] Univ Otago, Sch Pharm, Dunedin 9054, New Zealand

[2] Queensland Univ Technol, Brisbane, Qld 4001, Australia

[3] Univ Queensland, Sch Phys Sci, St Lucia Brisbane, Australia

来源：

JOURNAL OF BIOPHARMACEUTICAL STATISTICS | 2012年 / 22卷 / 06期

关键词：

D-optimal design; ED design; Nonlinear model; Pharmacokinetics; Robust design; Standard error; SAMPLING TIMES; EID;

D O I：

10.1080/10543406.2011.580484

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study compared the performance of a local and three robust optimality criteria in terms of the standard error for a one-parameter and a two-parameter nonlinear model with uncertainty in the parameter values. The designs were also compared in conditions where there was misspecification in the prior parameter distribution. The impact of different correlation between parameters on the optimal design was examined in the two-parameter model. The designs and standard errors were solved analytically whenever possible and numerically otherwise.

引用

页码：1193 / 1205

页数：13

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