Localization of ZIP14 and ZIP8 in HIBCPP Cells

被引：8
|
作者：
Morgan, Shannon E. [1 ]
Schroten, Horst [2 ]
Ishikawa, Hiroshi [3 ]
Zhao, Ningning [1 ]
机构：
[1] Univ Arizona, Dept Nutr Sci, Tucson, AZ 85721 USA
[2] Heidelberg Univ, Med Fac Mannheim, Dept Pediat, Pediat Infect Dis, D-68167 Mannheim, Germany
[3] Univ Tsukuba, Dept Neurosurg, Tsukuba, Ibaraki 3058575, Japan
来源：
BRAIN SCIENCES | 2020年 / 10卷 / 08期
基金：
美国国家卫生研究院;
关键词：
ZIP14; ZIP8; Manganese; HIBCPP; Blood-cerebrospinal fluid barrier; IN-VITRO MODEL; METAL-ION TRANSPORTER; CEREBROSPINAL-FLUID; ZINC TRANSPORTER; MANGANESE HOMEOSTASIS; EXPRESSION; IRON; DEFICIENCY; SLC39A8; BRAIN;
D O I：
10.3390/brainsci10080534
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The blood-cerebrospinal fluid barrier (BCB) is important in maintaining brain manganese (Mn) homeostasis. This barrier consists of a single layer of epithelial cells, connected by tight junctions, that restrict the passage of nutrients to only allow molecules to be carried through the membrane by a transporter. These epithelial cells are polarized with asymmetrical blood-facing and cerebrospinal fluid-facing sides. Here, we have established a polarized model of a human choroid plexus papilloma cell line, HIBCPP. For the first time, Mn importers ZIP14 and ZIP8 were identified in HIBCPP cells and were found to be enriched at the basolateral and apical sides of the cell monolayer, respectively. The localization of each ZIP protein adds to the understanding of Mn transport across the HIBCPP BCB model to help understand the mechanism of Mn homeostasis within the brain.
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页码：1 / 15
页数：15
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