Dystrophins in developing retina: Dp260 expression correlates with synaptic maturation

被引：32
|
作者：
Rodius, F
Claudepierre, T
RosasVargas, H
Cisneros, B
Montanez, C
Dreyfus, H
Mornet, D
Rendon, A
机构：
[1] UNIV STRASBOURG 1, CHRU, LAB PHYSIOPATHOL RETINIENNE, INSERM CJF 92 02, F-67091 STRASBOURG, FRANCE
[2] FAC PHARM MONTPELLIER, INSERM U300, MONTPELLIER, FRANCE
[3] CINVESTAV IPN, DEPT GENET & MOL BIOL, MEXICO CITY 14000, DF, MEXICO
来源：
NEUROREPORT | 1997年 / 8卷 / 9-10期
关键词：
development; dystrophin superfamily; Dp260; expression pattern; rat retina; RT-PCR;
D O I：
10.1097/00001756-199707070-00056
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
DYSTROPHIN, the protein altered in Duchenne muscular dystrophy (DMD), is necessary for normal retinal function and exists in several isoforms. We examined the expression of dystrophin and utrophin proteins and transcripts in the rat retina at different developmental stages using Western blots and semi-quantitative RT-PCR. Our results revealed the presence of utrophin (DRP1), G-utrophin and/or DRP2 and four dystrophin isoforms (Dp427, Dp260, Dp140, Dp71) in the normal adult rat retina. Only Dp260 showed a marked progressive increase with age at both protein and mRNA levels. This variation is consistent with the establishment of synaptic functions in the developing retina and suggests a key role for this apo-dystrophin in synaptogenesis.
引用
收藏
页码：2383 / 2387
页数：5
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