Inhibin gene promoter polymorphisms in Korean women with idiopathic premature ovarian failure

It has been suggested that variations in the inhibin gene (INHA) may affect the ovarian function of women. This study was performed to investigate whether the genetic polymorphisms of the INHA gene are associated with idiopathic premature ovarian failure (POF) in a Korean population. The subjects consisted of 159 idiopathic POF patients and 233 post-menopausal controls. Genotyping for the 16CT polymorphism was performed by an minor groove binder (MGB) primer/probe Taqman assay, and the 124AG polymorphism was identified using PCR restriction fragment length polymorphism analysis. Haplotypes were deduced by using the Haploview version 4.1. There were no significant differences in the genotype distributions or allele frequencies of the INHA gene 16CT and 124AG polymorphisms between the POF and the control group. Haplotype analysis also showed no significant difference between groups. The distribution of the INHA gene promoter polymorphisms in a Korean POF population was not significantly different from controls, implying that the INHA gene polymorphisms may not be associated with the risk of idiopathic POF.