SB 207266 is a potent 5-HT4 receptor antagonist in human isolated gastrointestinal tissue

被引：0
|
作者：
Wardle, KA [1 ]
Sanger, GJ [1 ]
机构：
[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AW,ESSEX,ENGLAND
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1997年 / 120卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：P192 / P192
页数：1
相关论文
共 50 条
  • [1] SB 207266: The first potent and selective 5-HT4 receptor antagonist amide with oral activity
    Wardle, KA
    Bingham, S
    Ellis, ES
    Gaster, LM
    Rushant, B
    Smith, MI
    Brown, AM
    Young, TJ
    Sanger, GJ
    BRITISH JOURNAL OF PHARMACOLOGY, 1996, 117 : P126 - P126
  • [2] A pharmacodynamic model of 5-HT4 receptor activation in man: Antagonism by the 5-HT4 receptor antagonist SB-207266
    Cooper, SM
    Haydock, SF
    Tompson, DJ
    Higgins, RG
    Fitzpatrick, KL
    GASTROENTEROLOGY, 1999, 116 (04) : A598 - A598
  • [3] Synthesis and pharmacological activity of metabolites of the 5-HT4 receptor antagonist SB-207266
    Fedouloff, M
    Hossner, F
    Voyle, M
    Ranson, J
    Powles, J
    Riley, G
    Sanger, G
    BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (08) : 2119 - 2128
  • [4] Piboserod hydrochloride -: SB-207266A -: Treatment of IBS -: 5-HT4 antagonist
    不详
    DRUGS OF THE FUTURE, 2000, 25 (12) : 1323 - 1323
  • [5] SB-204070 - A HIGHLY POTENT AND SELECTIVE 5-HT4 RECEPTOR ANTAGONIST
    WARDLE, KA
    ELLIS, ES
    GASTER, LM
    KING, FD
    SANGER, GJ
    BRITISH JOURNAL OF PHARMACOLOGY, 1993, 110 : P15 - P15
  • [6] Effects of a serotonin 5-HT4 receptor antagonist SE-207266 on gastrointestinal motor and sensory function in humans
    Bharucha, AE
    Camilleri, M
    Haydock, S
    Ferber, I
    Burton, D
    Cooper, S
    Tompson, D
    Fitzpatrick, K
    Higgins, R
    Zinsmeister, AR
    GUT, 2000, 47 (05) : 667 - 674
  • [7] SB203186, A POTENT 5-HT4 RECEPTOR ANTAGONIST, IN PORCINE SINOATRIAL NODE AND HUMAN AND PORCINE ATRIUM
    PARKER, SG
    HAMBURGER, S
    TAYLOR, EM
    KAUMANN, AJ
    BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 : P68 - P68
  • [8] Increased defecation during stress or after 5-hydroxytryptophan:: selective inhibition by the 5-HT4 receptor antagonist, SB-207266
    Sanger, GJ
    Yoshida, M
    Yahyah, M
    Kitazumi, K
    BRITISH JOURNAL OF PHARMACOLOGY, 2000, 130 (03) : 706 - 712
  • [9] SB-207266:: 5-HT4 receptor antagonism in human isolated gut and prevention of 5-HT-evoked sensitization of peristalsis and increased defaecation in animal models
    Sanger, GJ
    Banner, SE
    Smith, MI
    Wardle, KA
    NEUROGASTROENTEROLOGY AND MOTILITY, 1998, 10 (04): : 271 - 279
  • [10] Piboserod (SB 207266), a selective 5-HT4 receptor antagonist, reduces serotonin potentiation of neurally-mediated contractile responses of human detrusor muscle
    B. Darblade
    D. Behr-Roussel
    D. Gorny
    T. Lebret
    G. Benoit
    J.-P. Hieble
    D. Brooks
    L. Alexandre
    F. Giuliano
    World Journal of Urology, 2005, 23 : 147 - 151
12345