Preparation and Application of Ornidazole Magnetic Imprinted Polymers with Dual Functional Monomers

The magnetic molecularly imprinted polymers (MMIPs) was synthesized by suspension polymers technique using ornidazole (ONZ) as template, and methacrylic acid (MAA) and acrylamide (AA) as the binary functional monomers. The MMIPs were characterized by means of scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA) and ultraviolet. visible (UV-Vis) spectrophotometer. The results indicated that the adsorption capacity of MMIPs using the binary functional monomers to ONZ was higher than that using single functional monomer or that of its structural analogues. The Scatchard plot revealed that the template polymer system had a two. site binding behavior and the MMIPs exhibited the maximum rebinding to ONZ at 48. 96 mu mol/g and 10. 60 mu mol/g. Combined with high performance liquid chromatographic analysis technology, the prepared MMIPs were successfully applied to extract and enrich trace nitroimidazoles from river water samples with recoveries range of 85.4%-104.3%. The precision of the results was good, and the manipulation of the developed method was simple and fast comparing to other methods.