Asymmetric synthesis of isohaliclorensin, a key intermediate of bisquinolinylpyrrole alkaloid halitulin

被引：6

作者：

Usuki, Y ^{[1
]}

Hirakawa, H ^{[1
]}

Goto, K ^{[1
]}

Iio, H ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Sci, Dept Mat Sci, Sumiyoshi Ku, Osaka 5588585, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 23期

关键词：

D O I：

10.1016/S0957-4166(02)00007-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new enantioselective total synthesis of N-(3'-aminopropyl)-3-methylazacyclodecane, a partial structure of halitulin, has been achieved in eight steps with 14% overall yield. The key steps are the photochemical ring-expansion reaction of spirooxaziridine to lactam for constructing the azacyclodecane moiety and 1,4-stereoinductive methylation of the resulting lactam. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3293 / 3296

页数：4

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