Safety of topical calcineurin inhibitors in atopic dermatitis: Evaluation of the evidence

被引:33
|
作者
Spergel, Jonathan M. [1 ]
Leung, Donald Y. M. [1 ]
机构
[1] Univ Colorado, Hlth Sci Ctr, Div Pediat Allergy Immunol, Denver, CO 80206 USA
关键词
D O I
10.1007/s11882-006-0059-7
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Topical calcineurin inhibitors (pimecrolimus, Elidel, East Hanover, NJ; and tacrolimus, Protopic, Tokyo, Japan) have been approved for the use in atopic dermatitis since the year 2000. These compounds represent a relatively safe class of topical anti-inflammatory, nonsteroidal therapy. However, in January of 2006, the US Food and Drug Administration issued a black box warning on these compounds about possible concerns of increased long-term malignancy risk due to systemic immunosuppression. To date, studies from clinical trials, systemic absorption, and post-marketing surveillance show no evidence for this systemic immunosuppression or increased risk for any malignancy.
引用
收藏
页码:270 / 274
页数:5
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