Skeletal muscle mitochondria in health and disease

被引：21

作者：

De Mario, Agnese ^{[1
]}

Gherardi, Gaia ^{[1
]}

Rizzuto, Rosario ^{[1
]}

Mammucari, Cristina ^{[1
]}

机构：

[1] Univ Padua, Dept Biomed Sci, Padua, Italy

来源：

CELL CALCIUM | 2021年 / 94卷

关键词：

Mitochondrial calcium uptake; Skeletal muscle; Mitophagy; Mitochondrial myopathies; Fusion and fission machinery;

D O I：

10.1016/j.ceca.2021.102357

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondrial activity warrants energy supply to oxidative myofibres to sustain endurance workload. The maintenance of mitochondrial homeostasis is ensured by the control of fission and fusion processes and by the mitophagic removal of aberrant organelles. Many diseases are due to or characterized by dysfunctional mitochondria, and altered mitochondrial dynamics or turnover trigger myopathy per se. In this review, we will tackle the role of mitochondrial dynamics, turnover and metabolism in skeletal muscle, both in health and disease.

引用

页数：10

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