Multiparameter toxicity screening on a chip: Effects of UV radiation and titanium dioxide nanoparticles on HaCaT cells

被引：4
|
作者：
McCormick, Scott [1 ,2 ]
Smith, Louise E. [1 ]
Holmes, Amy M. [3 ]
Tong, Ziqiu [4 ]
Lombi, Enzo [1 ]
Voelcker, Nicolas H. [1 ,4 ,5 ]
Priest, Craig [1 ]
机构：
[1] Univ South Australia, Future Ind Inst, Mawson Lakes Campus,Mawson Lakes Blvd, Mawson Lakes, SA 5095, Australia
[2] Univ Bristol, Bristol BS8 1TQ, Avon, England
[3] Univ South Australia, Sch Pharm & Med Sci, Adelaide, SA 5000, Australia
[4] Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia
[5] CSIRO Mfg, Clayton, Vic 3168, Australia
来源：
BIOMICROFLUIDICS | 2019年 / 13卷 / 04期
基金：
澳大利亚研究理事会;
关键词：
ZINC-OXIDE NANOPARTICLES; PHOTOCATALYTIC ACTIVITY; OXIDATIVE DAMAGE; PARTICLE-SIZE; CYTOTOXICITY; SKIN; SILVER; INACTIVATION; ASSESSMENTS; MECHANISMS;
D O I：
10.1063/1.5113729
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Microfluidic screening is gaining attention as an efficient method for evaluating nanomaterial toxicity. Here, we consider a multiparameter treatment where nanomaterials interact with cells in the presence of a secondary exposure (UV radiation). The microfluidic device contains channels that permit immobilization of HaCaT cells (human skin cell line), delivery of titanium dioxide nanoparticles (TNPs), and exposure to a known dose of UV radiation. The effect of single-parameter exposures (UV or TNP) was first studied as a benchmark, and then multiparameter toxicity (UV and TNP) at different concentrations was explored. The results demonstrate a concentration-dependent protective effect of TNP when exposed to UV irradiation. Published under license by AIP Publishing.
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页数：8
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