Cytotoxic Activities, SAR and Anti-Invasion Effects of Butylphthalide Derivatives on Human Hepatocellular Carcinoma SMMC7721 Cells

被引：11
|
作者：
Hu, Yihan [1 ]
Bi, Xiaoxu [2 ]
Zhao, Pu [2 ]
Zheng, Huachuan [3 ,4 ]
Huang, Xueshi [1 ,2 ]
机构：
[1] China Med Univ, Lab Metab Dis Res & Drug Dev, Shenyang 110001, Peoples R China
[2] Northeastern Univ, Inst Microbial Pharmaceut, Coll Life & Hlth Sci, Shenyang 110819, Peoples R China
[3] Liaoning Med Univ, Affiliated Hosp 1, Canc Res Ctr, Key Lab Brain & Spinal Cord Injury Liaoning Prov, Jinzhou 121001, Peoples R China
[4] Liaoning Med Univ, Affiliated Hosp 1, Lab Anim Ctr, Jinzhou 121001, Peoples R China
来源：
MOLECULES | 2015年 / 20卷 / 11期
关键词：
Ligusticum chuanxiong; butylphthalides; cytotoxic activity; SAR; anti-invasion; LIGUSTICUM-CHUANXIONG; ANGELICA-SINENSIS; PHTHALIDES; BUTYLIDENEPHTHALIDE; CONSTITUENTS; ANTIFUNGAL; PLANTS;
D O I：
10.3390/molecules201119699
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of butylphthalide derivatives (BPDs) 1-8 were isolated from the extract of the dried rhizome of Ligusticum chuanxiong Hort. (Umbelliferae). The cytotoxic activities of BPDs 1-8 were evaluated using a panel of human cancer cell lines. In addition, the SAR analysis and potential anti-invasion activities were investigated. The sp(2) carbons at C-7 and C-7a appeared to be essential for the cytotoxic activities of BPDs. BPDs 5 and 6 remarkably inhibited the migration and invasion of cancer cells. The anti-invasion activity of dimer 6 was demonstrated to be significantly higher than monomer 5.
引用
收藏
页码：20312 / 20319
页数：8
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