Cutaneous Leiomyosarcoma The Clinical Experience of Taipei Veterans General Hospital Revisited

Background: Cutaneous leiomyosarcoma (CLM) is a rare soft tissue tumor of smooth muscle derivation. We report the clinical treatment, long-term outcomes, and prognostic findings of CLM in our institution. Materials and Methods: We revisited and carried out a retrospective chart review of 16 consecutive patients with CLM treated from 1991 through 2015. Patient demographic data, tumor size, location, previous treatment, follow-up data, and the presence or absence of recurrence were evaluated. Results: Therewere 6 males and 10 females (mean age, 48.6 years; range, 20-78 years). Clinical follow-up revealed local recurrences in 4 patients 1.3 to 72-months after surgical excision. No distant metastases were observed. We reviewed previously published articles and analyzed the clinical findings, pathologic examinations, and treatments. Conclusions: Surgical tumor excision with a wide lateral and deep margin is the most appropriate method. Other therapeutic methods such as radio-or chemotherapy provide no significant benefits. We recommend long-term follow-up of patients because recurrence is possible although not common.