Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer

被引：31

作者：

Ogasawara, Akira ^{[1
]}

Kamiya, Mako ^{[2
,3
]}

Sakamoto, Kei ^{[4
]}

Kuriki, Yugo ^{[1
]}

Fujita, Kyohhei ^{[2
]}

Komatsu, Toni ^{[1
]}

Ueno, Tasuku ^{[1
]}

Hanaoka, Kenjiro ^{[1
]}

Onoyama, Haruna ^{[4
]}

Abe, Hiroyuki ^{[5
]}

Tsuji, Yosuke ^{[6
]}

Fujishiro, Mitsuhiro ^{[7
,8
]}

Koike, Kazuhiko ^{[6
]}

Fukayama, Masashi ^{[5
]}

Seto, Yasuyuki ^{[4
]}

Urano, Yasuteru ^{[1
,2
,9
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[2] Univ Tokyo, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[3] Japan Sci & Technol Agcy, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan

[4] Univ Tokyo, Dept Gastrointestinal Surg, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan

[5] Univ Tokyo, Dept Pathol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan

[6] Univ Tokyo, Dept Gastroenterol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan

[7] Univ Tokyo, Dept Endoscopy & Endoscop Surg, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan

[8] Nagoya Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan

[9] Japan Agcy Med Res & Dev, AMED CREST, Chiyoda Ku, 1-7-1 Otemachi, Tokyo 1000004, Japan

来源：

BIOCONJUGATE CHEMISTRY | 2019年 / 30卷 / 04期

关键词：

SQUAMOUS-CELL CARCINOMA; PROTEASE;

D O I：

10.1021/acs.bioconjchem.9b00198

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have developed an activatable red fluorescence probe for dipeptidylpeptidase-W (DPP-IV) by precisely controlling the photoinduced electron transfer (PeT) process of a red fluorescent scaffold, SiR600. The developed probe exhibited an extremely low background signal and showed significant fluorescence activation upon reaction with DPP-IV, enabling sensitive detection of esophageal cancer in clinical specimens from cancer patients.

引用

页码：1055 / 1060

页数：6

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