Dissecting the genetics of longevity in Drosophila melanogaster

被引：67
|
作者：
Paaby, Annalise B. [1 ]
Schmidt, Paul S. [1 ]
机构：
[1] Univ Penn, Philadelphia, PA 19104 USA
来源：
FLY | 2009年 / 3卷 / 01期
关键词：
lifespan; longevity; aging genes; mutation screen; QTL; genetic variance; natural populations; evolution; QUANTITATIVE TRAIT LOCI; EXTENDS LIFE-SPAN; LONG-LIVED DROSOPHILA; AGE-SPECIFIC PATTERNS; STRESS RESISTANCE; REPRODUCTIVE DIAPAUSE; NATURAL VARIATION; OXIDATIVE STRESS; EVOLUTIONARY GENETICS; CORRELATED RESPONSES;
D O I：
10.4161/fly.3.1.7771
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Drosophila melanogaster has been an historically important system for investigating the genetic basis of longevity, and will continue to be valuable as new technologies permit genomic explorations into the biology of aging. The utility of D. melanogaster resides in two resources: its powerful genetic tools as a model system, and a natural ecology that provides substantial genetic variation across significant environmental heterogeneity. Here we provide a review of the genetics of longevity in D. melanogaster, in which we describe the characterization of individual aging genes, the complexity of the genetic architecture of this quantitative trait, and the evaluation of natural genetic variation in the evolution of life histories.
引用
收藏
页码：29 / 38
页数：10
相关论文
共 50 条
  • [1] Dissecting olfactory behavior in Drosophila melanogaster
    Alcorta, E
    Martin, F
    Gomez, C
    Charro, MJ
    [J]. BEHAVIOR GENETICS, 2002, 32 (06) : 459 - 459
  • [2] Steroid control of longevity in Drosophila melanogaster
    Simon, AF
    Shih, C
    Mack, A
    Benzer, S
    [J]. SCIENCE, 2003, 299 (5611) : 1407 - 1410
  • [3] Longevity determination genes in Drosophila melanogaster
    Aigaki, T
    Seong, KH
    Matsuo, T
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 2002, 123 (12) : 1531 - 1541
  • [4] GENETICS AND ACTIVITY IN DROSOPHILA MELANOGASTER
    EWING, AW
    [J]. EXPERIENTIA, 1967, 23 (05): : 330 - +
  • [5] Nectarine promotes longevity in Drosophila melanogaster
    Boyd, Olga
    Weng, Peter
    Sun, Xiaoping
    Alberico, Thomas
    Laslo, Mara
    Obenland, David M.
    Kern, Bradley
    Zou, Sige
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2011, 50 (11) : 1669 - 1678
  • [6] GENETICS OF AN ESTERASE IN DROSOPHILA MELANOGASTER
    WRIGHT, TRF
    [J]. GENETICS, 1963, 48 (06) : 787 - &
  • [7] Genetics of metallothioneins in Drosophila melanogaster
    Wang Yiwen
    Tian Xiaohan
    Zhu Chunfeng
    Yu Xiaoyu
    Miao Yaodong
    Qiao Huanhuan
    [J]. CHEMOSPHERE, 2022, 288
  • [8] GENETICS OF GEOTAXIS IN DROSOPHILA MELANOGASTER
    WALTON, PD
    [J]. CANADIAN JOURNAL OF GENETICS AND CYTOLOGY, 1968, 10 (03): : 673 - &
  • [9] Dissecting Motor Neuron Disease With Drosophila melanogaster
    Walters, Rachel
    Manion, John
    Neely, G. Gregory
    [J]. FRONTIERS IN NEUROSCIENCE, 2019, 13
  • [10] Dissecting the visual learning circuit in Drosophila melanogaster
    Vogt, K.
    Schnaitmann, C.
    Triphan, S.
    Tanimoto, H.
    [J]. JOURNAL OF NEUROGENETICS, 2012, 26 : 58 - 58
12345