The Role of Vesicle Release and Synaptic Transmission in Depression

被引：5

作者：

Zhang, Cheng-Cheng ^{[1
]}

Zhu, Li-Xia ^{[2
]}

Shi, Hu-Jiang ^{[1
]}

Zhu, Li-Juan ^{[1
]}

机构：

[1] Southeast Univ, Sch Med, Dept Histol & Embryol, Key Lab Dev Genes & Human Dis,MOE, Nanjing 210009, Jiangsu, Peoples R China

[2] China Natl Intellectual Property Adm CNIPA, Patent Examinat Cooperat JIANGSU Ctr, Patent Off, Suzhou 215163, Jiangsu, Peoples R China

来源：

NEUROSCIENCE | 2022年 / 505卷

基金：

中国国家自然科学基金;

关键词：

Vesicle release; Synaptic transmission; Neurotransmitter; Neuropeptide; Receptors; Depression; GLYCOGEN-SYNTHASE KINASE-3; LONG-TERM POTENTIATION; NMDA RECEPTOR ANTAGONISTS; RAT SUPRAOPTIC NUCLEUS; GLYCINE RECEPTORS; SIGNALING PATHWAY; MOLECULAR-BASIS; 5-HT3; RECEPTOR; NEUROTROPHIC FACTOR; PREFRONTAL CORTEX;

D O I：

10.1016/j.neuroscience.2022.10.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Depressive disorder is the leading cause of disability worldwide, yet the mechanisms underlying depression are not fully understood. Vesicle release is essential for synaptic neurotransmission, the abnormalities of vesicle release and synaptic plasticity are associated with various neuropsychiatric disorders. Neural circuits are ensembles of interconnected neurons that collectively perform specific functions. To some extent, depression may be caused by a disruption in the structural and functional connections of the neural circuits underlying emotion regulation. In this review, we summarized the role of abnormalities of vesicle release and synaptic transmission, as well as the related regulatory molecules and signal pathways in the regulation of depression. (C) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：171 / 185

页数：15

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