Development and Challenges in the Copper-Catalyzed Trifluoromethylation of Alkenes

被引：38
|
作者：
Liu, Xiaowu [1 ]
Wu, Xiaoxing [1 ]
机构：
[1] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
来源：
SYNLETT | 2013年 / 24卷 / 15期
基金：
美国国家科学基金会;
关键词：
trifluoromethylation; copper-catalyzed; migration; radical; allylic alcohol; NUCLEOPHILIC TRIFLUOROMETHYLATION; ELECTROPHILIC TRIFLUOROMETHYLATION; BOND FORMATION; TERMINAL ALKENES; FLUORINE; HYDROTRIFLUOROMETHYLATION; OXYTRIFLUOROMETHYLATION; REARRANGEMENT; EFFICIENT; PERFLUOROALKYLATION;
D O I：
10.1055/s-0033-1339684
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The recent trifluoromethylation of unactivated alkenes and related compounds provides a new and straightforward method to mainly form C-sp3-CF3 bonds. However, several mechanisms have been proposed for the system of copper catalysts and electrophilic trifluoromethylating reagents. This paper differentiated the radical mechanism from others experimentally and computationally by investigating the chemoselectivity in the rearrangement of unsymmetrical ,-diaryl allylic alcohols. Moreover, it outlines some future directions in this field.
引用
收藏
页码：1882 / 1886
页数：5
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