5-HT7 receptor stimulation by 8-OH-DPAT counteracts the impairing effect of 5-HT1A receptor stimulation on contextual learning in mice

被引：59

作者：

Eriksson, Therese M. ^{[1
,2
]}

Golkar, Armita ^{[1
]}

Ekstrom, Joanna C. ^{[1
]}

Svenningsson, Per ^{[2
]}

Ogren, Sven Ove ^{[1
]}

机构：

[1] Karolinska Inst, Dept Neurosci, Div Behav Neurosci, Stockholm, Sweden

[2] Karolinska Inst, Dept Physiol & Pharmacol, Sect Translat Neuropharmacol, Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2008年 / 596卷 / 1-3期

基金：

英国医学研究理事会;

关键词：

8-OH-DPAT 8-Hydroxy-2-(dipropylamino); tetralin; 5-HT1A receptor; 5-HT7; receptor; Contextual learning; Memory;

D O I：

10.1016/j.ejphar.2008.08.026

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The principal 5-HT1A receptor agonist 8-Hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT) impairs several different types of learning. Besides 5-HT1A receptors, 8-OH-DPAT stimulates 5-HT7 receptors, but it is not known whether 5-HT7 receptors contribute to the impairments. The 5-HT7 receptor antagonist (2R)-1-[(3Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl] pyrrolidine (SB-269970) was combined with S-OH-DPAT to dissociate 5-HT1A from 5-HT7 receptor-mediated effects, in the passive avoidance task for emotional learning. SB-269970 intensified impairments caused by 8-OH-DPAT. SB-269970 alone had no effect on memory performance, but moderately decreased retention under suboptimal learning conditions. These findings indicate that 5-HT7 receptor stimulation by 8-OH-DPAT counteracts 5-HT1A receptor-mediated impairments in hippocampal-dependent contextual learning. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：107 / 110

页数：4

共 50 条

[1] Role of 5-HT1A and 5-HT7 receptors in the facilitatory response induced by 8-OH-DPAT on learning consolidation
Meneses, A
Terrón, JA
BEHAVIOURAL BRAIN RESEARCH, 2001, 121 (1-2) : 21 - 28
[2] 8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents
Hedlund, PB
Kelly, L
Mazur, C
Lovenberg, T
Sutcliffe, JG
Bonaventure, P
EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 487 (1-3) : 125 - 132
[3] 8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents
Hedlund, P. B.
Sutcliffe, G.
Kelly, L.
Mazur, C.
Lovenberg, T.
Bonaventure, P.
FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2004, 18 : 147 - 147
[4] Intraseptal injection of the 5-HT1A/5-HT7 agonist 8-OH-DPAT and working memory in rats
Hélène Jeltsch
Fabrice Bertrand
Rodrigue Galani
Christine Lazarus
Sarah Schimchowitsch
Jean-Christophe Cassel
Psychopharmacology, 2004, 175 : 37 - 46
[5] Intraseptal injection of the 5-HT1A/5-HT7 agonist 8-OH-DPAT and working memory in rats
Jeltsch, H
Bertrand, F
Galani, R
Lazarus, C
Schimchowitsch, S
Cassel, JC
PSYCHOPHARMACOLOGY, 2004, 175 (01) : 37 - 46
[6] Effects of the 5-HT7 receptor antagonist SB-269970 on rat hormonal and temperature responses to the 5-HT1A/7 receptor agonist 8-OH-DPAT
Faure, Celine
Mnie-Filali, Ouissame
Scarna, Helene
Debonnel, Guy
Haddjeri, Nasser
NEUROSCIENCE LETTERS, 2006, 404 (1-2) : 122 - 126
[7] ATTENUATION OF CATALEPSY BY THE 5-HT1A/5-HT7 AGONIST, 8-OH-DPAT, IS MEDIATED BY POSTSYNAPTIC 5-HT RECEPTORS
RICK, CE
LACEY, MG
BRITISH JOURNAL OF PHARMACOLOGY, 1994, 112 : U33 - U33
[8] Phase-shifting effect of 8-OH-DPAT, a 5-HT1A/5-HT7 receptor agonist, on locomotor activity in golden hamster in constant darkness
Cutrera, RA
Saboureau, M
Pevet, P
NEUROSCIENCE LETTERS, 1996, 210 (01) : 1 - 4
[9] Strain differences in the response to the 5-HT1A receptor agonist, 8-OH-DPAT
Uphouse, L
Maswood, S
Jackson, A
Brown, K
Prullage, J
Myers, TB
Shaheen, F
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 72 (03) : 533 - 542
[10] 5-HT1A autoreceptors mediate the hyperphagic effect of 8-OH-DPAT in mice
Brosda, J.
Mueller, N.
Bert, B.
Fink, H.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2012, 385 : 16 - 16

← 1 2 3 4 5 →