KRAS and KIT Gatekeeper Mutations Confer Polyclonal Primary Imatinib Resistance in GI Stromal Tumors: Relevance of Concomitant Phosphatidylinositol 3-Kinase/AKT Dysregulation

被引：41

作者：

Serrano, Cesar ^{[1
,2
,3
]}

Wang, Yuexiang ^{[1
]}

Marino-Enriquez, Adrian ^{[1
]}

Lee, Jen-Chieh ^{[1
,4
]}

Ravegnini, Gloria ^{[1
,5
]}

Morgan, Jeffrey A. ^{[2
,3
]}

Bertagnolli, Monica M. ^{[1
]}

Beadling, Carol ^{[6
,7
]}

Demetri, George D. ^{[2
,3
]}

Corless, Christopher L. ^{[7
]}

Heinrich, Michael C. ^{[6
,7
]}

Fletcher, Jonathan A. ^{[1
,2
,3
]}

机构：

[1] Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Ludwig Ctr, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

[4] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Taipei 10764, Taiwan

[5] Univ Bologna, Bologna, Italy

[6] Oregon Hlth & Sci Univ, Portland Vet Affairs Med Ctr, Portland, OR 97201 USA

[7] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97201 USA

来源：

关键词：

V600E BRAF MUTATIONS; SUCCINATE-DEHYDROGENASE; MECHANISMS; INHIBITORS;

D O I：

10.1200/JCO.2013.48.7488

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：E93 / E96

页数：4